Development of patient-derived xenograft models of prostate cancer for maintaining tumor heterogeneity
نویسندگان
چکیده
منابع مشابه
Next generation patient-derived prostate cancer xenograft models
leading cause of cancer-related death of North American males.1 The disease is at present incurable once it has metastasized, and most deaths from this disease are due to metastases that are highly resistant to current conventional therapies. Prostate cancer is considered a multifocal disease that generally consists of a dominant cancer and one or more concurrent cancers of smaller volume with ...
متن کاملErratum: Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells.
A correction was made to Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells. There was a spelling error in one of the authors' surname. The author's name was corrected from: Veronica Rodriquez-Bravo to: Veronica Rodriguez-Bravo.
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Preclinical models often fail to capture the diverse heterogeneity of human malignancies and as such lack clinical predictive power. Patient-derived tumor xenografts (PDX) have emerged as a powerful technology: capable of retaining the molecular heterogeneity of their originating sample. However, heterogeneity within a tumor is governed by both cell-autonomous (e.g., genetic and epigenetic hete...
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ژورنال
عنوان ژورنال: Translational Andrology and Urology
سال: 2019
ISSN: 2223-4683,2223-4691
DOI: 10.21037/tau.2019.08.31